منابع مشابه
William Stokes 1804-78: the development of a doctor.
The name of William Stokes is familiar to all who practise medicine. His achievements in clinical medicine, and particularly in cardiology, are examples of clear thought and erudite expression. These qualities were not confined to the practice of clinical medicine; Stokes gave much thought to, and wrote sensitively about, the development of the doctor and his role in society. He believed that l...
متن کاملDmd053082 1797..1804
Aldehyde oxidase 1 (AOX1) is a cytosolic enzyme highly expressed in liver and plays a key role in metabolizing drugs containing aromatic azaheterocyclic substituents. Rapid metabolism catalyzed by AOX1 can cause a drug to exhibit high clearance, low exposure, and hence decreased efficacy or even increased toxicity (if AOX1 generated metabolites are toxic). There is a need to develop the correla...
متن کاملDmd058685 1795..1804
Permeability-glycoprotein (P-glycoprotein, P-gp), an efflux transporter at the human blood-brain barrier (BBB), is a significant obstacle to central nervous system (CNS) delivery of P-gp substrate drugs. Using positron emission tomography imaging, we investigated P-gp modulation at the human BBB by an approved P-gp inhibitor, quinidine, or the P-gp inducer, rifampin. Cerebral blood flow (CBF) a...
متن کاملDev101048 1794..1804
During organogenesis, various molecular and physical signals are orchestrated in space and time to sculpt multiple cell types into functional tissues and organs. The complex and dynamic nature of the process has hindered studies aimed at delineatingmorphogeneticmechanisms in vivo, particularly in mammals. Recent demonstrations of stem cell-driven tissue assembly in culture offer a powerful new ...
متن کاملKarl Sigmund.
Program Thursday, October 29 10:00 – 10:20 Opening addresses by Vice-Rector Prof. Dr. Heinz Faßmann and by Dean Prof. Dr. Harald Rindler 10:20 – 11:15 Peter Schuster: “Modeling cooperation – From molecules to man” 11:15 – 12:10 Martin Nowak: “Natural cooperation” 12:10 – 14:00 Lunch 14:00 – 14:55 Sebastian Schreiber: "Fitness covariances and coexistence of interacting, structured populations" 1...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1996
ISSN: 0022-3050
DOI: 10.1136/jnnp.60.6.683